Nov 17, 2025
Tricyclic Antidepressants and Antihistamines: The Hidden Danger of Anticholinergic Overload
Treatment-resistant depression affects 30-40% of people with depression. When standard antidepressants fail, augmentation with medications like aripiprazole or advanced therapies like rTMS and esketamine offer real hope. Evidence-backed options exist-here’s what works.
