Jan 15, 2026
Cmax and AUC in Bioequivalence: How Peak Concentration and Total Exposure Determine Generic Drug Equivalence
Learn how insurance covers generic drugs from online pharmacies, the difference between mail-order and independent retailers, and how to avoid unexpected costs. Know your formulary, check network status, and compare prices before ordering.
Cmax and AUC are the two key pharmacokinetic measures used to prove generic drugs work like brand-name versions. Cmax shows peak concentration, AUC shows total exposure-both must fall within 80%-125% for approval.
Authorized generics are identical to brand-name drugs but sold under a different label. In 2025, only 12 new ones were approved - down from 37 in 2022. Learn why they're disappearing and when they still matter.
Antitrust laws in the generic drug market prevent big pharma from blocking cheaper alternatives through pay-for-delay deals, patent manipulation, and product hopping. These tactics cost consumers billions-but enforcement is evolving.
